Scale Up

Sep 21, 2006
ePT--the Electronic Newsletter of Pharmaceutical Technology
By Pharmaceutical Technology Editors
Specialty Pharmaceutical Company Bentley Pharmaceuticals has entered into an agreement with Cardinal Health for the scale-up of clinical supplies for Bentley's intranasal insulin product candidate.
Sep 12, 2006
ePT--the Electronic Newsletter of Pharmaceutical Technology
By Pharmaceutical Technology Editors
Arlington, VA (Sept. 12)—At the American Association of Pharmaceutical Scientists meeting here, &quote;Real World Applications of PAT and QbD in Drug Process Development and Approval" (Sept. 11-12), chemical engineer and process modeler Michael L. Thompson, PhD, described how Procter & Gamble (West Chester, OH, www.pg.com) applies these mathematical tools to increase product quality and reduce development and trouble-shooting time for consumer and pharmaceutical products.
Oct 02, 2005
Pharmaceutical Technology
By Pharmaceutical Technology Editors
Although agitation improves drying efficiency and ensures uniformity of the final dry material, it can also affect the physical properties of the product as it dries. This study evaluates the effect of scale up and equipment selection on an active ingredient undergoing granulation during the drying process.
Mar 01, 2005
Pharmaceutical Technology
By Pharmaceutical Technology Editors
In the manufacture of many pharmaceutical products, dry-particle blending is a critical step that directly affects content uniformity.
Mar 01, 2005
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The author points out some major obstacles to effective scale-up and describes methods available to pharmaceutical scientists for addressing scalability issues.
Mar 01, 2005
Pharmaceutical Technology
By Pharmaceutical Technology Editors
The author reviews dimensional analysis as a straight-forward approach to scale up.
Nov 01, 2004
Pharmaceutical Technology
By Pharmaceutical Technology Editors
This article describes a novel approach to a scale-up management system, based on a holistic view of the scale-up lifecycle and an accompanying electronic development record of the information created.
Nov 02, 2001
Pharmaceutical Technology
Poly(vinyl acetate) phthalate-based and acrylic-based enteric coating systems are evaluated for their performance on acetylsalicylic acid tablets in areas such as acid resistance and coated-tablet stability.
Aug 01, 2001
Pharmaceutical Technology
Careful planning and decision-making can circumvent possible delays in technology transfers.
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