Editors' Picks of Pharmaceutical Science & Technology Innovations
Plant managers must design manufacturing processes that function efficiently and ensure patient safety. Line operations should run smoothly and avoid wasting expensive materials. In addition, processes should not provide opportunities for contamination or unintended reactions that could affect a medicine's appearance or activity. These considerations apply to all aspects of production, including the packaging process. Two of this month's products provide packaging solutions that guard against contaminants that could compromise product quality. The third product is a storage option for bulk ingredients that supports efficient manufacturing by maximizing product discharge and improving flow into process equipment.
Syringe system is silicone-free
The syringe system is presterilized and requires no component preparation for filling in customers' equipment. The Flurotec film and sterilized Crystal Zenith material ensure that drug-contact surfaces are inert and clean. The system contains few extractables.
The 1-mL luer-lock syringe system accepts various needle gauges. The syringe barrel incorporates a nozzle cap that seals the luer fitting until the needle is added. The system is suitable for packaging and administering biopharmaceuticals. The absence of silicone prevents the system from causing protein aggregation or particle formation in biopharmaceutical drugs.
Capping machines are designed for isolators
The "VRK" series overseal capping machines from Bosch Packaging Technology (Crailsheim, Germany) are designed for use in isolators. The machines' sealing and mechanical-drive systems enable unidirectional air flow and help sweep particles away from the capping operation.
In addition, the VRK units use pneumatic force to compress stoppers and caps. Sensors verify that seals are properly and consistently crimped regardless of vial-height variations.
Flexible silos optimize space
Each silo stores as much as 7000 ft3 of dry bulk material and supports weights as great as 90,000 lbs. The containers' square design optimizes the use of space. Customers can specify outlet parameters such as diameter, cone angle, and discharge aids, and the units are compatible with common conveyor types. The silos are suitable for short-term and pilot-plant storage applications.
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