Editors' Picks of Pharmaceutical Science & Technology Innovations
To ensure that a tableting process will be predictable, active ingredients and excipients in powder form must undergo granulation. This process results in granules, which comprise several particles each, and helps personnel produce tablets within the desired specifications. This month's products aid the granulation process in various ways. A vibratory feeder from K-Tron conveys cohesive powders into the granulation process. Oystar's high-shear mixers help ensure uniform blends during the operation. A sensor from Natoli allows personnel to monitor materials as they are granulated.
Sensor provides speed and sensitivity
The LIF sensor incorporates onboard control sensors, such as reference photodiodes, an accelerometer, a thermal monitor, and various diagnostic tools, that help to provide high-quality data. The device's data output occurs every 100 ms, and this fast response time enables employees to make production decisions.
The LIF Sensor can verify tablets' API content and is suitable for analyzing low-dose, high-potency drugs. Personnel also can use the device to monitor material during granulation, detect the end point of blending operations, and aid in cleaning verification.
Vibratory feeder conveys cohesive ingredients
Mixers enable high yields
For granulation lines, Oystar links the mixer units to HDGC fluid beds. Process air is forced through radial slots in the fluid bed's discjet, thus setting the product in motion as soon as it is transferred from the mixer. This feature increases material's wall speed and starts the drying process instantly. One of the fluid bed's five independent filters is blown back at any given time, and the unit constantly uses 80% of its maximum filtration area.
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