Editors' Picks of Pharmaceutical Science & Technology Innovations
The production lines that create small- and large-molecule dosage forms can be long and complex. Each step of the process must be monitored carefully to ensure that the resulting drug product meets its specifications and is free from contaminants. This month's products help manufacturers understand and control their production processes. Updated software from Yokogawa makes it easier than before for users to find and view process data. Mettler Toledo's workstation allows operators to ensure the safety of chemical reactions. Personnel can monitor several cell-culturing processes in real time with Stratophase's optical microchips.
Control system eases access to information
In addition, the Centum VP software's operator interface uses frames and structured windows to simplify access to data and displays. Users can move between tabs with keystrokes to find information quickly, rather than calling up a new display or linking to a separate display. Yokogawa also has modified the software's trend display system. A single screen allows users to compare batches' performance with that of a reference batch.
Technology allows real-time monitoring of cell cultures
Workstation enables control of strong reactions
Using information collected by the thermostat, the system calculates data such as heat transfer coefficients, specific heats, heat-flow rates, and thermal accumulation. The workstation converts basic data into crucial safety information. The safety runaway graph describes failure scenarios and helps users avoid runaway reactions, and a graph indicates the process's level of criticality.
The system is controlled by flexible software that integrates with online analytical tools. Operators can run predefined, automated procedures; directly control individual process steps with the system; or combine both approaches.