Editors' Picks of Pharmaceutical Science & Technology Innovations
As science advances and regulations evolve, new classes of products become available. Recent years, for example, have witnessed increased emphasis on highly potent products and biopharmaceuticals. As patients' demands change, drugmakers must have the proper equipment to produce needed medicines. This month's products help manufacturers respond to public demand and regulatory requirements. A tablet press from Manesty produces scalable results. Biocontainers from Meissner provide thermal stability for sensitive products. Emerson's pinch valve helps provide precise flow control.
Tablet press enables adjust-ments to precompression force
The tablet press includes load cells that analyze precompression, main compression, ejection, scrape-off, and punch-tightness forces. A servo motor and encoder for the turret calculate theoretical punch displacement, which tells personnel the exact position of the punch at all times. One paddle feeder fills the necessary amount of powder into the dies and replicates powder feed behavior at production scale.
Biocontainers provide chemical resistance
Pinch valve automates control of sterile liquids
The Baumann 85000 can clamp around existing disposable tubing, which enables the user to bypass extractables and leachables testing on the liner, thus ensuring compatibility with the liquid-control process and compliance with FDA requirements. Its tube–shell design eliminates the need to replace the liner with each batch, which simplifies changeout of disposable tubing between batches and reduces users' inventory. Its epoxy-coated actuator features stainless-steel fasteners that enhance corrosion resistance. Also, the valve plunger does not contact the process fluid and operates with a shutoff rating equal to ASME/FCI 70-2, Class VI.