Equipment and Processing Report-02-15-2012

Equipment and Processing Report

Mid-Size Extruders Enable Scale-Up of Hot-Melt Extrusion

February 15, 2012

Production Lines

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With the increasing use of hot-melt extrusion, extruder manufacturers have developed mid-size twin-screw extruders that facilitate process development and scale-up to commercial processes.

Determining Whether Dry-Dispersion Can Be Used in a Laser-Diffraction System

February 15, 2012

Troubleshooting

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We need to measure the particle size of a moisture-sensitive powder. We would like to use dry analysis on our laser-diffraction system, but the particles are fragile and we're struggling to get robust results. Is wet measurement with a nonaqueous solvent the only option?