Pharmaceutical Technology-04-01-2008

Pharmaceutical Technology

Advances in Radio-Frequency Transdermal Drug Delivery

April 01, 2008

Drug Delivery

2008 Supplement

1

A microelectronic system based on radio-frequency (RF) cell ablation addresses limitations of other transdermal drug-delivery methods. This system expands the transdermal spectrum to include the delivery of water-soluble molecules, peptides, proteins, and other macromolecules.

Polypeptide Multilayer Nanofilms in Drug Delivery

April 01, 2008

Drug Delivery

2008 Supplement

1

Investigators are exploiting the tremendous structural diversity of polypeptides and their biophysical properties to develop novel drug carriers. Peptide-based materials hold out much promise for tailor-made targeting, penetration, and release of contents in a host of biological microenvironments.

Dissolvable Films: Dissolvable Films for Flexible Product Format in Drug Delivery

April 01, 2008

Drug Delivery

2008 Supplement

1

For pediatric and geriatric patients, fast-dissolving drug-delivery systems provide an easier way to take medications and vitamins. Oral thin films have evolved to provide systemic delivery of active pharmaceutical ingredients for over-the-counter and soon, prescription drugs. The authors review the practical benefits of dissolvable films, their manufacture, and their market potential.

Challenges in the Secondary Manufacture of Encapsulated High-Potency Drugs

April 01, 2008

Drug Delivery

2008 Supplement

1

Liquid and semisolid encapsulation using two-piece hard capsules is an ideal drug delivery approach for highly potent compounds and poorly water-soluble drugs. The authors detail the factors to reduce risk when designing and operating a facility for secondary manufacturing of highly potent drugs.