Effect of Formulation and Process Variables on Matrix Erosion and Drug Release from a Multiunit Erosion Matrix of a Poorly Soluble Drug

M. Serpil Kislalioglu, PhD

M. Serpil Kislalioglu, PhD, is a professor of pharmaceutics at the Department of Applied Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, Kingston, RI 02881, tel. 401.874.5017, fax 401.874.2181.

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Ketan A. Mehta, PhD

Ketan A. Mehta, PhD, is a technical services manager at Röhm Pharma Polymers, Degussa Corporation.

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Navnit H. Shah

Navnit H. Shah is a distinguished research leader, all at the pharmaceutical and analytical research and development department of Hoffman–La Roche Inc. (Nutley, NJ).

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Wantanee Phuapradit, PhD

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A. Waseem Malick, PhD

A. Waseem Malick, PhD, is vice-president at the pharmaceutical and analytical research and development department of Hoffman–La Roche Inc. (Nutley, NJ).

Pharmaceutical Technology, Pharmaceutical Technology-02-02-2002, Volume 26, Issue 2

By optimizing formulation and process varibles, pellets can be prepared that can release a poorly soluble drug for 12-24 h following zero-order kinetics.