New Technology Advances Biopharma Chromatography Productivity (Feb 2023)
Biologics manufacturers have been successful boosting yields and increasing throughput in upstream mAbs production. Those increased volumes create a new challenge: scaling downstream process chromatography to be as productive. This Avantor white paper details how technologies such as a novel protein A chromatography resin and the use of additives can improve efficiencies in this complex process step. The white paper also explores the benefits of expanding single-use and continuous processing systems to further streamline downstream production and improve cost profiles.
The Role of On-Demand Manufacturing and Derisking in Accelerating Early Clinical Trial Success
June 4th 2025Small pharmaceutical companies are constantly seeking innovative solutions to streamline early clinical trials. Adaptive clinical trials offer important benefits to sponsors and patients, both from a commercial and ethical standpoint. These trials offer flexibility and efficiency, especially in the early stages, where trial protocols can be adjusted based on interim data, such as introducing new doses or modifying participant sample size. However, adjusting manufacturing demand during an adaptive trial can be complicated, and strict regulatory requirements present significant challenges. On-demand manufacturing provides a robust solution, allowing for real-time supply and demand adjustments and improved trial flexibility. This paper explores how on-demand manufacturing meets the operational needs of adaptive trials and aligns with regulatory expectations.
Fast and Efficient Sialic Acid Clone Selection Using Lectin-Based High-Throughput Screening
June 2nd 2025Glycosylation is a common and critical post-translational modification that affects protein function and therapeutic efficacy, making its monitoring and accurate quantification essential for drug development.
