In pharmaceutical formulations, phospholipids obtained from plant or animal sources as well as synthetic phospholipids are used. Synthetic phospholipids possessing natural stereochemical configuration are preferably synthesized from sn-glycero-3-phosphocholine (GPC), using acylation and enzyme catalyzed reactions. The precursor GPC can be obtained from naturally occurring phospholipids.
In addition to natural phospholipids, synthetic phospholipids are becoming increasingly important in drug delivery, as can be seen from the number of drug products containing synthetic phospholipids. They mainly play a role in parenteral administration and inhalation dosage forms. Parenteral and inhalation products with synthetic phospholipids comprise liposomal formulations, lipid nanoparticles, diagnostic products, and dry powders for inhalation, respectively. Examples of intravenous products are provided in Table 1.
Synthetic phospholipids are used in parenteral depot formulations as well (Table 2).
Synthetic phospholipids can also be found in vaccines, in the form of lipid nano particles (LNPs) or liposomes in recently developed vaccine formulations for intramuscular administration for the delivery of messenger ribonucleic acid (mRNA) and a disease-related antigen, respectively. LNPs are also used for maintenance treatment of patients with chronic obstructive pulmonary disease intravenous administration of small interfering RNA (siRNA) in the treatment of rare diseases (Table 3).
Synthetic phospholipids in relevant inhalation products are listed in Table 4. Interestingly, the phospholipids are used in several types of formulations suitable for commonly used inhalation devices.
In the future, synthetic phospholipids and designer lipids may play a more important role in sophisticated drug delivery systems.
The SCIEX clinical diagnostic portfolio is For In Vitro Diagnostic Use. Rx Only. Product(s) not available in all countries. For information on availability, please contact your local sales representative or refer to https://sciex.com/diagnostics. All other products are For Research Use Only. Not for use in Diagnostic Procedures. Trademarks and/or registered trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners in the United States and/or certain other countries. © 2020 DH Tech. Dev. Pte. Ltd. RUO-MKT-19-10922-A