Understanding Break-loose & Glide Force Behavior in Prefilled Syringe Systems

Prefilled syringes are an ideal drug delivery system due to easier administration, reduced risk of contamination, minimized risk of injuries during use and improved accuracy. In this webcast, learn why it is critical to ensure that prefilled syringes are designed to be patient-friendly and meet the regulatory guidelines.

Register Free: https://www.pharmtech.com/pt/break-loose

Event Overview:

Prefilled syringes (PFS) are effective drug-delivery systems that are patient-friendly and conserve drug product. Though these systems offer clear advantages as a drug delivery platform, their designation as combination products offer additional regulatory challenges. As a combination product, the mechanical functionality of the syringe-elastomer system is an important consideration. An element to consider is the break-loose force (BL) and gliding force (GF) profile.
In this webcast, the importance of a patient-appropriate BL & GF profile and the importance of optimization for efficacious drug-delivery will be discussed, in addition to:

• Factors that affect BLF & GF profiles
• Force exertion considerations for different patient populations
• Strategies for elastomer selection to optimize BL&GF profiles for consistent performance

Key Learning Objectives

• Know the challenges faced by pharmaceutical companies when producing a PFS system
• Understand how the interplay between elastomer, barrel, and silicone impacts functional behavior like the BLF & GF
• Gain insight into interactions at the elastomer/ barrel interface and discuss elastomeric options that can help to improve consistency with BLF & GF curve

Who Should Attend

• Quality/regulatory personnel in parenteral drug delivery
• Formulation scientists and packaging engineers
• Device development engineers and managers
• Technical functions surrounding drug delivery systems
• Extractable and leachable experts
• Procurement professionals

Speaker

Katie Falcone graduated with a B.S. degree in Biomedical Engineering from Drexel University in Philadelphia, PA. After finishing her undergraduate studies, she joined West Pharmaceutical Services where she served in several technical roles. In 2021 Katie graduated with her M.S.E. in Bioengineering from the University of Pennsylvania in Philadelphia. Katie has focused both her career and educational pursuits around primary parenteral packaging systems from research and development to implementation in medical devices to scientific consultation to support commercialization. Katie joined Datwyler in 2021 as a Scientific Support Manager. She collaborates with pharmaceutical companies in the selection of parenteral packaging solutions for safe and efficacious drug-delivery.

Register Free: https://www.pharmtech.com/pt/break-loose