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Melanie Sena is community editor of Pharmaceutical Technology.
Bioreactor Functions as Perfusion Mimic
TAP Biosystem’s ambr micro bioreactor system can be applied as a perfusion mimic to enable scientists to quickly develop large-scale perfusion culture processes of unstable, low producing or minimally expressing proteins or antibodies. This system can be used as a semi-continuous chemostat model for perfusion culture in 10-15 mL micro bioreactors by using the workstation’s integrated cell counter to monitor cell density and calculate both cell growth rates and dilution volumes required to maintain stable cell density. The liquid handling performs dilutions at appropriate time points, which automatically refines chemostasis throughout the culture process. The cell specific performance can then be extrapolated to full-scale perfusion cultures.