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Melanie Sena is community editor of Pharmaceutical Technology.
Hybrid Purifer Enhances Efficiency
3M’s Emphaze AEX Hybrid Purifier combines polymers, fine fiber nonwovens, and membranes to create an all-synthetic clarifying product line containing anion exchange nonwoven media and a fine particle, bioburden reduction membrane. The defined pore size of the qualifying membrane provides removal of insoluble particles below 0.1 µm in size, resulting in turbidity reduction. In addition, the high chromatographic capacity of the Q-functional nonwoven provides reduction of negatively charged, soluble impurities including DNA and HCP. This combination of attributes allows the hybrid purifier to provide product purity before and after the Protein A column, enabling an easy post-Protein A mAb purification process. According to the company, this purifier can improve the production of mAb drugs for various cancers, as well as autoimmune diseases such as rheumatoid arthritis and psoriasis.
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