Inorganic DNA Replication Enzyme

Published on: 
Pharmaceutical Technology, Pharmaceutical Technology, October 2022, Volume 46, Issue 10
Pages: 12

The new inorganic pyrophosphate from Canvax is intended for use in RNA IVT reactions.

Canvax’s new inorganic pyrophosphatase is a DNA replication enhancer with ≥ 95% purity and has an enhanced capacity for increasing RNA yield in in-vitro transcription (IVT) reactions. The enzyme, which is isolated from Escherichia coli, has demonstrated stability below 80ºF, and is free of endonucleases, exonucleases, and RNAases.

The enzyme is intended for use in RNA IVT reactions, as it is designed to reduce the inhibitory effects of protein-protein interactions. In addition, it is suitable for use in messenger RNA-based vaccine manufacturing, RNA labeling, and enhancement of DNA replication.