Measurement of Intrinsic Drug Dissolution Rates Using Two Types of Apparatus

June 2, 2001
Pharmaceutical Technology, Pharmaceutical Technology-06-02-2001, Volume 25, Issue 6

The evaluation of the intrinsic dissolution rate of an active pharmaceutical ingredient can be used to demonstrate chemical purity and equivalency. The authors used a rotating disk system and a stationary disk system to determine the intrinsic dissolution rates of various model drugs.