
This study evaluates the quantitative effects of the nature and concentrations of disintegrants and a tablet's relative density on disintegrant properties such as disintegration time and the crushing strength-friability/disintegration time ratio.
Gbenga Alebiowu, PhD, is a senior lecturer at the department of pharmaceutics, Obafemi Awolowo University, Ile-Ife, Nigeria.

This study evaluates the quantitative effects of the nature and concentrations of disintegrants and a tablet's relative density on disintegrant properties such as disintegration time and the crushing strength-friability/disintegration time ratio.

This comparative study suggests that pregelatinized starches are superior to natural starches in terms of improving the plastic deformation in tablet formulations during compression.

Published: September 1st 2001 | Updated:

Published: August 2nd 2003 | Updated: