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Enhanced brain drug delivery and targetingThe blood–brain barrier (BBB) forms an interface between the circulating blood and the brain, and functions as a tremendously effective barrier for the delivery of potential neurotherapeutics into the brain parenchyma. Conversely, the BBB possesses various carrier-mediated transport systems for the uptake of small molecules, such as essential nutrients and vitamins. These transporters have become an attractive target for drug/prodrug design in an attempt to ferry drug molecules across the BBB. Central nervous system (CNS) drug delivery is often limited by poor brain penetration of the potential drug candidate. As a result of its unique barrier properties, the BBB poses a huge challenge for the delivery of potential neurotherapeutics into the brain parenchyma.1 It is estimated that only 2% of small-molecule drugs and ,0.1% of novel protein and peptide pharmaceuticals developed for CNS diseases reach therapeutic concentrations in the brain.2,3 Many of the pharmacologically active drugs tend to fail..
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20th Anniversary Special Feature: The time for process understandingWhen Pharmaceutical Technology Europe was established 20 years ago, PAT was not a hot topic in the industry. It was started in 2002 by FDA to modernize pharmaceutical manufacturing and increase the efficiency of manufacturing processes.
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Quality by Design for analytical methods for use with orally inhaled and nasal drug productsThe design of accurate and robust analytical methodology is instrumental to developing orally inhaled and nasal drug products (OINDPs) and their appropriate control programmes.
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Achieving Aseptic Drying With Spray Drying TechnologiesHenrik Schwartzbach, senior process technologist at GEA Niro, explins why spray drying is seeing increased uptake in the pharma industry.
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The recovery mission – coping with validation failuresPractical guidance on how to handle validation failures cannot be found in the existing literature because they are not supposed to happen.
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Successful strategies for product optimization...an uninformed decision based on commercial requirements alone may, ultimately, have disastrous consequences on the efficacy of the target recombinants.
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20th Anniversary Special Feature: The impact of regulationsDuring the past two decades, regulations have evolved in both Europe and the US to accommodate the technological developments in the pharmaceutical, biotechnology and medical device industries.
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PVA copolymer: the new coating agentThe use of PVA copolymer-based film can solve the problems associated with lack of film adhesion... to tablets containing large amounts of waxy excipient or a lubricant.
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Quality by Design for analytical methods for use with orally inhaled and nasal drug productsThe design of accurate and robust analytical methodology is instrumental to developing orally inhaled and nasal drug products (OINDPs) and their appropriate control programmes.
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Dessicants for Pharmaceutical ApplicationsThis article examines the different types of dessicants avaliable to the pharmaceutical industry. It provides information on choosing the right type, and how and when it should be used.
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The counterfeit detectiveAs counterfeiters become more cunning and technologically advanced, spotting their handiwork is increasingly difficult. Can surface analysis techniques be used to outwit them?
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PVA copolymer: the new coating agentThe use of PVA copolymer-based film can solve the problems associated with lack of film adhesion... to tablets containing large amounts of waxy excipient or a lubricant.
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Where have we reached with REACH?The EU has changed history and set the pace for future productrelated legislation with its Registration, Evaluation and Authorization of Chemicals (REACH) Regulation no. 1907/2006, which came into effect in June 2007.
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Peer-Reviewed Technical Note: Quality by Design in Freeze-DryingCycle design and robustness testing using advanced process analytical technology.
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Solid dosage forms from self-emulsifying lipidic formulationsSpraying techniques can be used to produce powder form formulations. The concept works by the adsorption/absorption of a liquid SELF onto a neutral carrier…
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Information-Technology Criteria in CMO Selection and ManagementA sponsor company must investigate the manufacturing automation and systems, laboratory automation and systems, information-technology infrastructure, and business applications of each potential contract manufacturing organization.
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Current status in buccal drug deliveryThe adequate absorption and transport of drugs in the body is part of optimal therapy. Drug administration perorally is easy, common and traditional, but occasionally alternative routes are required.
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Handling difficult samples in bio-analytical chemical analysisThere are two ways in which 'difficult' samples are usually categorized: either by the problems posed by the physical nature of the post-vivo sample matrix containing the chemical entity to be analysed, or...
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PVA copolymer: the new coating agentThe use of PVA copolymer-based film can solve the problems associated with lack of film adhesion... to tablets containing large amounts of waxy excipient or a lubricant.
Latest:
Quality by Design for analytical methods for use with orally inhaled and nasal drug productsThe design of accurate and robust analytical methodology is instrumental to developing orally inhaled and nasal drug products (OINDPs) and their appropriate control programmes.
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Improving liposome integrity and easing bottlenecks to productionThe importance of liposomes as an effective drug delivery system is well accepted in the pharmaceutical industry, but their handling remains a challenge.
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Using Industry 4.0 to Optimize Oral Solid Dosage Form ManufacturingReal-time monitoring and the principles of quality by design were used to optimize an OSD coating process.
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Enhanced brain drug delivery and targetingThe blood–brain barrier (BBB) forms an interface between the circulating blood and the brain, and functions as a tremendously effective barrier for the delivery of potential neurotherapeutics into the brain parenchyma. Conversely, the BBB possesses various carrier-mediated transport systems for the uptake of small molecules, such as essential nutrients and vitamins. These transporters have become an attractive target for drug/prodrug design in an attempt to ferry drug molecules across the BBB. Central nervous system (CNS) drug delivery is often limited by poor brain penetration of the potential drug candidate. As a result of its unique barrier properties, the BBB poses a huge challenge for the delivery of potential neurotherapeutics into the brain parenchyma.1 It is estimated that only 2% of small-molecule drugs and ,0.1% of novel protein and peptide pharmaceuticals developed for CNS diseases reach therapeutic concentrations in the brain.2,3 Many of the pharmacologically active drugs tend to fail..
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The influence of concomitant use of alcoholic beverages on hypromellose matrix tabletsResearch shows that both drug prescription and alcohol consumption increase within the elderly population. It is, therefore, necessary to fully understand the impact of alcohol consumption on solid oral dosage forms, especially extended release formulations.
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Formulating Topical Products Containing Live Microorganisms as the Active IngredientCase studies compare efficacy testing of preservatives for topical formulations with probiotic actives.
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Verification Methods for 198 Common Raw Materials Using a Handheld Raman SpectrometerUsing handheld Raman spectroscopy, methods were developed and evaluated for 198 substances widely used as raw materials.
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EC Reviews: An Executive Country Review on TurkeyIn the wake of economic growth, healthcare reforms, and large-scale industry investment, Turkish pharmaceutical companies are charting their own destiny.
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Compliance in an Outsource Manufacturing Model: What to Look ForThe authors provide detailed lists of important checkpoints to consider when selecting an outsourcing provider.
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Formulation effects on the thermomechanical properties and permeability of free films and coating filmsUnderstanding a formulation's variable effects on its properties, especially film permeability, is key to designing a robust formulation and reducing variation of a finished product.
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Process Considerations During API DevelopmentThis article looks at how to adopt a systematic and prospective approach in the API development process to achieve documented, controlled synthetic processes...
