Advances in Ion-Exchange Chromatography Leading to Increased Efficiencies and Reduced Costs

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New ion-exchange chromatography media are more tolerant of varying conditions, making it possible to eliminate process steps.

Ion-exchange chromatography is often a crucial component of the downstream processing of biopharmaceuticals. Innovative new exchangers with new ligand chemistries are making it possible to increase selectivity and capacity. Some also are tolerant of high salt conditions, enabling the elimination of some preparative steps. Jim Powell, business development manager with Asahi Kasei Bioprocess, Estelle Zelter, global product manager of ion-exchange chromatography at EMD Millipore, and Sylvio Bengio, head of scientific communications for the global chromatography group at Pall Life Sciences, spoke with Cynthia Challener, editor of the Pharmaceutical Sciences, Manufacturing & Marketplace Report, about recent developments in ion-exchange chromatography technology that are benefiting their pharmaceutical customers.

Capacity and selectivity are key