PharmTech AI Pulse Check panelists explain why attribution, audit trails, and sign-off matter more than AI watermark detection for GxP quality teams.
News|Articles|June 6, 2016
Amyris and Janssen Collaborate on Biosynthetic Drug Discovery
Author(s)Pharmaceutical Technology Editors
Amyris will use its platform technology to develop a library of natural and natural-like compounds to test against Janssen’s therapeutic target.
Advertisement
On June 6, 2016 Amyris, an industrial bioscience company, entered into a research agreement with a commercial license option, with Janssen Biotech, a subsidiary of Janssen Pharmaceutical Companies. Under the terms of the agreement, facilitated by Johnson & Johnson Innovation, the collaboration will use Amyris’s µPharm platform technology to develop a customized library of natural and natural-like compounds to test against Janssen’s therapeutic target, Amyris said in a press announcement. The µPharm platform technology enables an integrated discovery and production process for therapeutic compounds. The platform creates diversity based on natural compound scaffolds.
"We are helping to take some of the guess work out of new drug discovery, which helps our partners, like Janssen, to be able to more quickly understand target interaction and ultimately discover new therapies faster," said Joel Cherry, Amyris's president, R&D.
According to the press announcement, Amyris will use the µPharm platform technology to develop a library of compounds and test their efficacy in-vivo for hits against Janssen’s identified target. The µPharm platform starts with the target, identifies candidate natural compound structures, and then creates diversity around those structures for in-vivo testing.
Source: Amyris
Advertisement
Related to this article
Ron Scarboro, Azurity Pharmaceuticals, explains how cross-functional development, disciplined reformulation, and post-approval metrics can help proven medicines work in everyday use.
The FDA approves oral pritelivir for drug-resistant herpes sores in immunocompromised patients; what it means for antiviral development and manufacturing.
This week, drug formulation and manufacturing experts showcased their knowledge, and companies exhibited their products, at CPHI Milan.
FDA approves Teva’s Weltruza, a once-monthly subcutaneous olanzapine for schizophrenia whose copolymer depot eliminates post-injection monitoring.
Equivalence test using two one-sided tests are widely used for demonstrating the comparability of treatment effects in different research fields. The method described in the manuscript aims to use simulations in Microsoft Excel to compute power for 2 one-sided tests for two groups with unequal variances.
Richard Jaenisch examines whether FDA's NAM pathway truly shortens drug pipelines or just shifts the evidentiary burden elsewhere.
Susan J. Schniepp, distinguished fellow with Nelson Labs, and Siegfried Schmitt, PhD, vice president, Technical, with Parexel, clear up some of the confusion about what does and does not need to be complied with regarding standards set by international pharmacopoeias.
Advertisement
Advertisement