AstraZeneca entered a collaboration with Bicycle Therapeutics for the identification and development of bicyclic peptides.
Bicycle Therapeutics announced on Dec. 1, 2016 that the company has entered a collaboration with AstraZeneca for the identification and development of bicyclic peptides for the treatment of respiratory, cardiovascular, and metabolic diseases. Bicycles, a novel class of small molecule medicines, exhibit target specificity associated with antibodies but in a small-molecule format, enabling rapid tissue penetration and flexible routes of administration.
Under the terms of the agreement, Bicycle is responsible for identifying Bicycles for an undisclosed number of targets specified by AstraZeneca while AstraZeneca is responsible for further development and product commercialization. If all planned programs reach the market, Bicycle will be eligible for over $1 billion in payments, including an upfront payment, future R&D funding, development, regulatory, and commercialization milestone payments. Bicycle would also be entitled to receive royalties on sales of products resulting from the collaboration.
Source: Bicycle Therapeutics
A Novel, Enhanced, and Sustainable Approach to Audit Trail Review
July 4th 2025Eli Lilly and Company developed an innovative and sustainable approach to audit trail review (ATR) aimed at reducing the ATR burden while adhering to regulatory expectations and data integrity (DI) principles. The process has transformed employees' understanding of ATR and complemented the DI by design approach, leading to better system designs that meet expected controls and reduce non-value-added data reviews.
Drug Solutions Podcast: A Closer Look at mRNA in Oncology and Vaccines
April 30th 2024In this episode fo the Drug Solutions Podcast, etherna’s vice-president of Technology and Innovation, Stefaan De Koker, discusses the merits and challenges of using mRNA as the foundation for therapeutics in oncology as well as for vaccines.
Drug Solutions Podcast: Gliding Through the Ins and Outs of the Pharma Supply Chain
November 14th 2023In this episode of the Drug Solutions podcast, Jill Murphy, former editor, speaks with Bourji Mourad, partnership director at ThermoSafe, about the supply chain in the pharmaceutical industry, specifically related to packaging, pharma air freight, and the pressure on suppliers with post-COVID-19 changes on delivery.