Establishing Target Fills for Semisolid and Liquid Dosage Forms

April 2, 2005

Pharmaceutical Technology, Pharmaceutical Technology-04-02-2005, Volume 29, Issue 4

To meet the requirements of the USP ^755& Minimum Fill and ^698& Deliverable Volume tests, target fill levels greater than 100% must be established.This article proposes a criterion for establishing an appropriate target fill level such that a sample will have a 95% probability of passing these USP tests at 95% confidence.