Estimation of Distribution Coefficients from the Partition Coefficient and pKa

Publication
Article
Pharmaceutical TechnologyPharmaceutical Technology-11-02-2002
Volume 26
Issue 11

For a monovalent species, a simple calculation that does not assume partitioning of the ionized species in the oil phase can provide an accurate estimate of the distribution coefficient.

External Link - article-38266.pdf

Articles in this issue
Contract Services
Major Changes Ahead for FDA
Estimation of Distribution Coefficients from the Partition Coefficient and pKa
Residual Solvent Analysis in Pharmaceuticals
Preparation and In Vitro Evaluation of Miconazole Nitrate-Loaded Topical Liposomes
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