Estimation of Distribution Coefficients from the Partition Coefficient and pKa

November 2, 2002

Douglas C. Scott, PhD is a senior scientist at the Procter & Gamble company, Health Care Research Center, 8700 Mason-Montgomery Rd., Mason, Ohio 45040, tel. 513.622.2434, fax 513.622.2522.

Pharmaceutical Technology, Pharmaceutical Technology-11-02-2002, Volume 26, Issue 11

For a monovalent species, a simple calculation that does not assume partitioning of the ionized species in the oil phase can provide an accurate estimate of the distribution coefficient.