Estimation of Distribution Coefficients from the Partition Coefficient and pKa

Scott,Douglas;

Publication

Article

November 2, 2002

Pharmaceutical Technology

Pharmaceutical Technology-11-02-2002

Volume26

Issue 11

Estimation of Distribution Coefficients from the Partition Coefficient and pKa

Author(s):

Douglas C. Scott, PhD

For a monovalent species, a simple calculation that does not assume partitioning of the ionized species in the oil phase can provide an accurate estimate of the distribution coefficient.

External Link - article-38266.pdf

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Estimation of Distribution Coefficients from the Partition Coefficient and pKa

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