L.B. Bohle continuous production unit
Together with a consortium from industry and academia L.B. Bohle developed the continuous processing unit for pharmaceutical solid dosage forms. In contrast to existing systems, Bohle´s modular system allows the flexible arrangement of different unit operations, opening the path for a specialized solution depending on the requirements of the customer. In this way the three most commonly production layouts direct compression, wet granulation and dry granulation can be realized. The inclusion of dry compaction in a continuous working process is unique and it is much more economic and less energy intensive in contrast to wet granulation.
The software integration, in turn, forms the basis of permanent monitoring, controlling, and documentation of the continuous production process. Advanced spectroscopy technologies, e.g. NIR and Raman, enable precise measurement and analysis during the individual production steps. By the integrated analytics the interim storage and the laboratory analytics will mostly become obsolete. The manufacturing process will be also reduced, allowing higher production capacities and faster response to short-term demands. With the continuous processes the scale up of the production output is achieved by extending the production time, rather than by batch sizes.
The unit provides a nominal output range of approx. 5 to 25 kg/h.
Contact Details :
L.B. Bohle Maschinen +Verfahren GmbH
Website: www.lbbohle.com
E-mail: t.borgergers@lbbohle.de
Transformations in Drug Development for Cell and Gene Therapies
March 28th 2025As a recognized leader in immunophenotyping for clinical trials, Kevin Lang from PPD discusses how spectral flow cytometry is transforming drug development, particularly in cell and gene therapies like CAR-T. He also dives into his award-winning research, including his 2024 WRIB Poster Award-winning work, and his insights from presenting at AAPS PharmSci360.
Advancing Clinical Trials with Spectral Flow Cytometry: A Conversation with Kevin Lang
March 28th 2025As a recognized leader in immunophenotyping for clinical trials, Kevin Lang from PPD discusses how spectral flow cytometry is transforming drug development, particularly in cell and gene therapies like CAR-T. He also dives into his award-winning research, including his 2024 WRIB Poster Award-winning work, and his insights from presenting at AAPS PharmSci360.
Innovative Solutions in Pre-Filled Syringes for Biologics and Ophthalmic Applications
May 5th 2025Don't miss this webinar delving into: - How to streamline the selection of the primary container and delivery device - How to overcome silicone challenges in PFSs - How to enhance the delivery of highly viscous drug formulation
Solving the Silicone Challenge in Pre-fillable Syringes
May 5th 2025The release of subvisible silicone particles and the risks associated with silicone oil droplets are major factors that can compromise the safety and efficacy of sensitive drugs. Download this white paper and discover how Stevanato Group's innovative syringe platform answers this challenge.
