News|Articles|September 2, 2001

Pharmaceutical Technology

  • Pharmaceutical Technology-09-02-2001
  • Volume 25
  • Issue 9

A Novel Mathematical Method for Quantitative Expression of Deviation from Zero-Order Drug Release

Because drug delivery at a zero-order rate provides uniform concentration of a drug for absorption, this study attempts to identify a simple mathematical method to quantitatively express the deviation from zero-order kinetics.


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Equivalence test using two one-sided tests are widely used for demonstrating the comparability of treatment effects in different research fields. The method described in the manuscript aims to use simulations in Microsoft Excel to compute power for 2 one-sided tests for two groups with unequal variances.