Optimizing the Sterilization of Liquids in Sealed Containers

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Pharmaceutical TechnologyPharmaceutical Technology-05-15-2014
Volume 2014 eBook
Issue 2

sterilization approach-cycles controlled by differential pressure-is described.

 

Establishing a sterilization process for liquids in containers involves trial and error, as pressure adjustments must be made during the heating, sterilization, and cooling phases. An alternate approach-cycles controlled by differential pressure-maintains the pressure in the chamber at a level that prevents the rigid containers from exploding and the non-rigid containers from becoming deformed.

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Continuous Bioprocessing Challenges
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Achieving and Maintaining Compliance Using Continuous Monitoring Systems
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Optimizing the Sterilization of Liquids in Sealed Containers
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Using Modular Systems in Biopharmaceutical Manufacturing
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Determining Protein Oxidation Induced During Fill-Finish Operations
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Single-Use Technology in Parenteral Fill/Finish
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