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Pharmaceutical Technology

Pharmaceutical Technology-05-15-2014
Volume2014 eBook
Issue 2

Optimizing the Sterilization of Liquids in Sealed Containers

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sterilization approach-cycles controlled by differential pressure-is described.

 

Establishing a sterilization process for liquids in containers involves trial and error, as pressure adjustments must be made during the heating, sterilization, and cooling phases. An alternate approach-cycles controlled by differential pressure-maintains the pressure in the chamber at a level that prevents the rigid containers from exploding and the non-rigid containers from becoming deformed.

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