Optimizing the Sterilization of Liquids in Sealed Containers

Published on: 
Pharmaceutical Technology, Pharmaceutical Technology-05-15-2014, Volume 2014 eBook, Issue 2

sterilization approach-cycles controlled by differential pressure-is described.


Establishing a sterilization process for liquids in containers involves trial and error, as pressure adjustments must be made during the heating, sterilization, and cooling phases. An alternate approach-cycles controlled by differential pressure-maintains the pressure in the chamber at a level that prevents the rigid containers from exploding and the non-rigid containers from becoming deformed.