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The new resin used a combination of “jetting” technology and a high-performance Protein A ligand.
On June 28, 2018, Purolite Life Sciences, a provider of chromatography resins, announced the commercialization of a new next-generation Protein A agarose resin, Praesto Jetted A50. The company has combined “jetting” technology with a new, high-performance Protein A ligand, NGL-Impact A (Repligen). “Jetting” technology is an innovative process that produces uniform-size agarose beads with a narrow particle-size distribution.
In multiple successive trials, Praesto Jetted A50 has consistently shown significantly improved performance over current Protein A resins due to the unique benefits of a new ligand coupled to a novel jetted-base matrix. The resulting new agarose-based Protein A resin delivers better performance in terms of capacity, pressure flow, and lifetime, according to the company. In addition, in-process bioburden risks and cross-contamination are managed more effectively because higher concentrations of sodium hydroxide can be used.
“Innovation is at the heart of this new Protein A resin and is the result of over 70 years combined expertise between Purolite’s jetted resin innovation, together with Repligen’s ligand technology expertise. Jetted resins provide superior performance characteristics over traditional resins, including improved pressure flow, resolution, and packing reproducibility due to the bead uniformity. This new resin addresses the increased titers from today’s bioreactors and allows customers to increase productivity from the same manufacturing footprint,” said Chris Major, global sales director at Purolite Life Sciences, in a company press release.
“We are very pleased to be working with Purolite Life Sciences supplying our new high performance NGL-Impact ligand, developed in collaboration with Navigo GmbH. We look forward to seeing how the ligand performs in the marketplace in combination with jetted agarose technology,” added Steve Tingley, vice president of sales at Repligen.
The production of jetted agarose bead technology is environmentally friendly because it eliminates organic solvents such as toluene commonly used in traditional manufacturing and is a major advancement in “green manufacturing”.
“Over the last five years we have focused on innovation and investment, leveraging nearly four decades of resin expertise, applying this to our protein A portfolio and commercializing our jetting bead technology. Our commitment to the Life Sciences industry is deep and I am delighted that we have launched not only a best in class Protein A resin with Praesto Jetted A50 but in the autumn of 2018 we will also bring on line our state of the art 100,000 L UK agarose manufacturing facility, which, combined with Repligen’s comprehensive business continuity plans, addresses vital security of supply requirements within the industry,” said Don Brodie, executive vice president at Purolite Life Sciences, in the press release.
Source: Purolite Life Sciences