Using Extrusion-Spheronization to Develop Controlled-Release Formulations of Azithromycin

Pharmaceutical Technology, Pharmaceutical Technology-02-02-2005, Volume 29, Issue 2

Extrusion-spheronization and pellet compression are effective means of developing first-order kinetic, controlled-release drug delivery systems of azithromycin (AZI). The authors prepared, evaluated, and optimized AZI formulations and assessed the stability of the selected formulation under accelerated storage conditions.