LC-30A Nexera — the cleanest and fastest UHPLC ever to date

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Shimadzu?s new LC-30A Nexera is unsurpassed in high-speed and high-resolution analysis and productivity. It meets the needs of the most demanding markets such as pharmaceutical and the food industry.

UHPLC systems represent the latest development in liquid chromatography instrumentation. Beside enhancements necessary to operate with sub 2 µm particle columns, they differ from each other through their versatility in handling various applications on the same instrument without any changes.

Nexera pumps offer a flow range from 0.0001 ml/min up to 3ml/min with 130 MPa pressure and from 3.0001 up to 5 ml/min with 80 MPa pressure. This allows the use of longer columns for covering fast LC with high flow rates and short columns as well as highest resolution using long columns.

The pumping systems allow use of binary and ternary high pressure gradients as well quaternary gradients. Two types of micro reactor-based mixing devices support a small system volume with very short gradient delays.

The Nexera autosampler provides reduced carryover compared to the previous instruments by keeping the direct injection with isolated metering system principle using 3 rinse solvents, various rinsing modes and design changes at needle and needle seal. To increase the throughput overlapping pre-treatment can be used. The pre-treatment capabilities expand the application range of this instrument.


LC-30A Nexera can be used for semi-micro, conventional and UHPLC methods without changes on the flowline. It fulfils the demands of an all-round LC system with high reliability and robustness. The modular concept of this system enables the setup of special systems such as online SPE and comprehensive LCXLC.

Designed especially for use with the system – the newly developed Shim-Pack XR ODS III columns with 1.6 µm particles provide maximum resolution, fast separation and high reliability in routine use.

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