Shimadzu has introduced its new Nexera-e comprehensive LCxLC system. The instrument combines two orthogonal separation modes to separate even the most complex mixtures, such as structural analogues in food and natural extracts, in just one analysis. The "e" implies exponentially better chromatography due to an exponential increase in peak capacity and resolution, enabling the analysis of multiple compounds and identification of chemical class patterns in a single chromatogram. One injection and sample preparation instead of several approaches underlines the system's efficiency.