Transferring Energy to Hot Melt Extrusions

Friday, April 5, 2024 at 11amEDT | 10am CDT | 8am PDT

Quality by design (QbD), and process analytical technology (PAT) are essential tools in hot melt extrusion (HME) processes, to enhance product and process understanding. Gain a greater understanding of HME about OSD manufacturing, and how advances in continuous processes are shaping the sector.

Register Free: https://www.pharmtech.com/pt_w/hot-melt-extrusions

Event Overview:

In this exclusive Drug Digest video interview, Chris Spivey, Editorial Director, Pharmaceutical Technology, talks with industry experts about various aspects of drug formulation, through the lens of hot melt extrusion (HME) technology. HME is typically co-located with downstream processing and solid dose form manufacturing. Regulatory bodies continue to encourage quality management maturity (QMM), quality by design (QbD), and process analytical technology (PAT), - essential tools in the HME processes, to enhance product and process understanding. As a continuous process, HME is aptly suited to this framework. PAT tools including Raman and near-infrared (NIR) spectroscopy play an important role in real-time quality evaluation, and understanding of the extrusion process, in the production pharmaceutical dosage forms. Solid dispersion intermediate (SDI) appears to be the result of gel formation and osmogens. Counteracting SDI involves some tradeoffs including pore formation and (potentially) the types of pores formed. We will ask what role HME might play in leverahging this aspect of solid dose form manufacturing.

This episode of Drug Digest is sponsored by:

• Veltek
• Adare
• Aprecia

Key Learning Objectives:

• How HME enhances solubility/bioavailability for poorly soluble drugs
• Why continuous processing allows for good process control & scalability
• Role of solvents, solvent behavior and amorphous solid dispersions
• HME potential incorporation in controlled release delivery formulations
• Ability to incorporate taste masking

Who Should Attend:

• Medicinal chemists
• CDMOs
• Formulation scientists
• Manufacturers
• Excipient and API manufacturers
• Purchasers and supply chain
• QA/QC personnel
• R&D personnel
• Development scientists

Speakers:

Industry Experts in Hot Melt Extrusion

Register Free: https://www.pharmtech.com/pt_w/hot-melt-extrusions