Updated GC-MS Systems for HRAM Sample Analysis

Pharmaceutical Technology's In the Lab eNewsletter

In the Lab eNewsletter, Pharmaceutical Technology\'s In the Lab eNewsletter-01-10-2018, Volume 13, Issue 1

Thermo Fisher Scientific’s Orbitrap GC-MS systems has new capabilities in high-resolution accurate mass for laboratories performing gas chromatography mass spectrometry.

Thermo Fisher Scientific’s Orbitrap GC-MS systems have new capabilities suited to provide highly sensitive, selective, and accurate compound identification of complex samples for both research and routine laboratories performing gas chromatography mass spectrometry (GC-MS).

The brand’s Q Exactive GC system provides data for compound discovery, identification, and quantitation for comprehensive analyses. The Exactive GC system delivers sensitive, routine-grade performance in both targeted and non-targeted screening protocols. Both systems provide improved resolving power, mass accuracy, linear dynamic range, and sensitivity of Orbitrap technology.

Features now include the addition of variable electron voltage (VeV) technology for electron ionization (EI), the brand’s high-resolution accurate mass (HRAM) metabolomics library, and the TraceFinder automated compound identification. The VeV technology enables low electron voltage settings to be used during EI protocols, promoting high mass signals and providing high sensitivity for compounds prone to extensive fragmentation, according to the company.

In the HRAM metabolomics library for EI, metabolite identification is streamlined. The library includes more than 800 metabolites, and the spectra is refined and curated with the elemental composition of each EI fragment verified. New TraceFinder software features a specialized spectral deconvolution library and automated compound identification to enable identification of challenging compounds. According to the company, with the addition of Kovats retention index to the scoring index of unknowns, user confidence in compound identification is improved, specifically in relation to isomeric compounds.

Source: Thermo Fisher Scientific