Pharmaceutical Technology Europe-10-01-2005

One of the most important skills any editor must possess is the ability to listen to their audience — without feedback, we don't get an opportunity to develop our publications; to not act on feedback shows plain ignorance. I must, therefore, give my personal thanks to the many hundreds of readers who participated in the Pharmaceutical Technology Europe (PTE) editorial and readership survey, which we conducted earlier this summer. Your comments and opinions will help us develop PTE, and we already have a number of exciting plans for 2006. Stay tuned!

One of the world leaders in the manufacture of tablet compression tooling, I Holland, is offering a range of machines for the automatic polishing of tablet compression tooling.

Essentially, RAD is a set of tools…that allows for rapid prototyping and reiterative testing that enable faster development and implementation of new applications.

In the pharmaceutical world it is generally accepted that a valve can be exchanged for another when it becomes defective, provided that the new one is exactly the same as the old one.

In-process methods are key components of quality control in a chemical manufacturing plant. These methods ensure that a production reaction step conducted by trained operators within the entire validated process will produce a quality chemical entity in the expected yields. The presence of impurities and related compounds (derived from the reaction or secondary reactions) is a critical parameter that determines a synthetic material's quality.

Regulatory and compliance requirements are frequently changing, and if that wasn't enough there is also numerous varying regulations across products, services and countries.

Picking may occur when granulation becomes imbedded on a punch surface and does not freely release when the compressing event has finished.

Chemical purity is the most important quality characteristic of a pharmaceutical substance. This article describes the latest scientific and technological advances to meet recent pharmacopoeial and regulatory requirements regarding the control of organic impurities in synthetically produced active substances. Future developments and suggestions for those working in quality control and raw material selection are discussed.

Dust extraction and centralized vacuum cleaning systems vary in their design, performance and costs. Different companies have different approaches to their design, however, there are some basic rules that must be followed if these systems are going to be immediately effective and avoid future problems.