Case Study: Retrofitting Two New High-Purity Water Systems

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Pharmaceutical Technology, Pharmaceutical Technology-05-15-2017, Volume 2017 eBook, Issue 1
Pages: s18-s26

The existing, obsolete highpurity water generation system and water-forinjection generation system were replaced with new, reliable technologies.

GlaxoSmithKline (GSK)’s R&D Biopharmaceutical Pilot Plant in Upper Merion, PA is a R&D clinical trial material (CTM) manufacturing facility with an aggressive processing schedule that requires minimal shutdown interruptions. Utility reliability is paramount to achieve production demands and regulatory quality requirements.

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To meet the utility demands for increased CTM output, a capital investment project was required to replace the existing, obsolete high purity water (HPW) generation system and water-for-injection (WFI) generation system with new, reliable technology.

This article describes how the new systems were designed and installed in a challenging space to ensure redundancy and improve sustainability.

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