Too Much by Half: Misapplication of the Half-Cycle Approach to Sterilization

News
Article
Pharmaceutical TechnologyPharmaceutical Technology-11-15-2016
Volume 2016 eBook
Issue 3
Pages: s21–s26

The half-cycle method for validating sterilization can have adverse effects on materials if used for steam sterilization.

The half-cycle method for validating sterilization, although necessary in its original context of ethylene oxide sterilization, can have adverse effects on materials if used for steam sterilization.

The author describes some of these potential results and reviews historical and current thinking on validation of sterilization processes.

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Articles in this issue
PTeBook1116_QMS_185.jpg
Extending QMS to Contract Partners
PTeBook1116_Agalloco_sterilization_185.jpg
Too Much by Half: Misapplication of the Half-Cycle Approach to Sterilization
PTeBook1116_HumanPerformance_BPOG_185.jpg
Investigation Effectiveness Drives Human Performance Excellence
PTeBook1116_Aging_Facilities_185.jpg
Is Global Regulatory Gridlock Slowing Modernization?
PTeBook1116_Instant_GMP_185.jpg
Paperless Batch Records for the Masses
PTeBook1116_Pharma_Report_Card_185.jpg
Could Greater Transparency Improve Pharmaceutical Quality and Compliance?
PTeBook1116_Capsugel_185.jpg
Ensuring Quality in Pharmaceutical Raw Materials
PTeBook1116_MicrobialTesting_Challener_185.jpg
Microbiological Testing: Time is of the Essence
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