Chromatography Solution for Biologic Drugs

The 3M Polisher ST from 3M Health Care is a single-use anion exchange (AEX) chromatography solution intended to replace the reusable AEX polishing column for biologic drug manufacturing. The new synthetic, fully encapsulated, single-use membrane chromatography solution contains two AEX-functional media: a quaternary ammonium functional nonwoven for the reduction of turbidity, DNA, and endotoxin; and a guanidinium-functional membrane for host-cell protein and virus reduction in a salt-tolerant manner.

Continuous bioprocessing allows facilities to reduce their size and cycle times, the compact product increases biomass production in therapeutic recombinant protein processes in all operating conditions.