Inline Probe Measures Particle Size in Real Time

March 18, 2015

A probe enables real-time monitoring of agglomeration, coating, and granulation.

The Parsum IPP-80 probe from Malvern Instruments enables inline particle-size measurement for real-time monitoring of agglomeration, coating, and granulation processes. The probe is suitable for powders, pellets, and granules, and a robust, sanitary design includes built-in, self-diagnostic tools that ensure data quality. 

Particle size is a performance-defining characteristic. During granulation, for example, control of particle size may be vital to ensure the production of granules that meet the requirements of subsequent processing steps and deliver the required performance in a finished product. Inline particle-size distribution measurement enables robust process monitoring and control. In the pharmaceutical industry, these capabilities support the application of quality by design, scoping of design space, and the development of continuous manufacturing.

The Parsum IPP-80 inline probe provides continuous particle size and size distribution data using the technique of spatial filter velocimetry. Measuring in the range of 50 µm to 6000 µm, the probe is able to analyze powders as well as pellets and large granules. Stable optics mean that the probe is resistant to the effects of vibration and requires no manual alignment. The software includes a range of diagnostic features for measurement verification and self-diagnosis to ensure trouble-free operation and safeguard data quality. 

Source: Malvern