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The Thermo Scientific Pharma mini implant line is an integrated solution built around the Thermo Scientific Pharma mini HME twin-screw micro compounder.
The Thermo Scientific Pharma mini implant line is an integrated solution for polymer-based drug implant development and production using hot-melt extrusion (HME). Built around the Thermo Scientific Pharma mini HME twin-screw micro compounder, the continuous, automated production line minimizes formulation development time. The line allows contract research and manufacturing organizations to develop and optimize small-scale formulations before engaging in larger-scale production.
Components of the line include a containment valve to add the API and the polymer, designed to protect the operator from exposure to the API and prevent contamination of the API; a gravimetric feeder to deliver the API/polymer into the micro compounder for heating and mixing before the melt is extruded through a die that creates a continuous filament; new bi-axial lasers that measure the thickness or diameter of the filament to adjust the stretching or “take-off” speed of the conveyor belt; and proprietary equipment that cuts the filament to a desired implant length while maintaining “roundness” without deforming the implant shape.