Microbioreactor System

Sartorius Stedim Biotech’s Generation 2 ambr 15 cell culture microbioreactor system offers increased flexibility and expanded capability for clone selection, media and feed optimization, and early process development work. The system replicates laboratory-scale bioreactor performance at the 10–15 mL microscale and controls up to 48 single-use bioreactor cultures in parallel.

Features include new functionality and a one-year license of the company’s clone selection software. Election of clones, media, and feeds can be performed under perfusion mimic conditions to bleed large volumes of culture and quickly remove spent media from the microbioreactors. A flexible workstation layout and an expanded tip bin capacity provide greater operator walk-away time, according to the company. New culture passage steps and rapid vessel drain functionality allow for the adaptation of cell lines to different media for media screening studies to be performed in the microbioreactors.

New media mixing steps automate the creation of media blends, eliminating the need to pre-mix. Rapid vessel drain functionality for automated cell passaging and media exchanges in the microbioreactors supports cell and gene therapy applications. A new culture station design provides lower stirrer speed control suitable for more sensitive cell lines.

Sartorius Stedim Biotech