Univar Solutions scientists developed a lidocaine cream built on starch, sorbitol, coconut oil, and beeswax that matched a commercial benchmark on viscosity, assay, and hydration.
|Articles|February 2, 2019
- Pharmaceutical Technology-02-02-2019
- Volume 43
- Issue 2
Multi-Shaft Mixer and Disperser
The Ross VersaMix is a multi-shaft mixer suited for viscous applications requiring a high level of accuracy and batch-to-batch consistency.
The Ross VersaMix is a multi-shaft mixer suited for viscous applications requiring a high level of accuracy and batch-to-batch consistency.
Available in standard sizes from 1- to 4000-gallon capacity, the mixer offers simple and reliable scalability from product development to full-scale production. Two or three independently-driven agitators work in tandem to ensure high-speed fine dispersion, efficient turnover, and uniform heating/cooling. Mixer features are tailored to a specific formulation or range of products for maximum functionality.
The VMC-200 model has a maximum working capacity of 200 gallons. An air/oil lift raises and lowers the agitators into the vacuum-rated vessel. All product contact surfaces are stainless-steel type 316L polished 180-grit finish. The ASME 60-psi jacket on the vessel is insulated with two-inch thick mineral wool and sheathed with water-tight stainless-steel cladding.
Equipped with a 10HP anchor agitator, 20HP disperser, and 25HP rotor/stator, the mixer delivers a combination of laminar bulk flow and intensity necessary for homogenization and deagglomeration in high-viscosity conditions up to several hundred thousand centipoises. The vacuum cover includes multiple charging ports, viewing windows, tank light, and a thermoprobe. Finished product is discharged out of a three-inch pneumatically-actuated diaphragm valve installed on the tank’s conical bottom.
Articles in this issue
over 7 years ago
Spectroscopy Facilitates Lean Analysisover 7 years ago
Fundamentals of GMP Warehouse Designover 7 years ago
Effective Root Cause Determinationover 7 years ago
Process Development Best Practices for Topical Drug Productsover 7 years ago
FDA Promotes Quality Standards to Reduce Shortagesover 7 years ago
Small-Batch Aseptic Fill/Finish Systemover 7 years ago
Automatic Desiccant Inserterover 7 years ago
Sterile Boot Coversover 7 years ago
Innovations Maintain the Cold Chainover 7 years ago
Advances in Engineering of Protein-Based APIsRelated to this article
Nate Edwards of Arya Consulting moderates a discussion with Elisabeth Gardiner of Tevard Biosciences and Donny Xu of the RTW Institute about the regulatory and manufacturing hurdles facing rare disease drug developers.
FDA grants ravulizumab accelerated approval in IgA nephropathy after a 43.4% proteinuria cut, signaling new IV biologic demand for drug manufacturers.
Jane Zhang of ETCH Sourcing explains why geopolitics, transparency, and partnership now weigh as heavily as cost and quality when companies choose suppliers, in this episode of Ask the Expert, moderated by Susan J. Schniepp of Nelson Labs.
FDA approves GSK's bepirovirsen for chronic hepatitis B after a 19% functional cure rate, raising oligonucleotide scale-up stakes for manufacturers.
Ravi Kiran Kaja, PhD, USP, explains what harmonization of extractables and leachables standards looks like in practice.
Jaenisch, Muraru, and Pandey discuss new skills for QC and regulatory teams, plus patient trust, as new approach methodologies reshape pharma.
Nine duloxetine recalls since 2024 show why generic drug manufacturers need route-level nitrosamine risk assessment, not end-product testing alone.
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