The Zeta Plus Encapsulated Filter System from diversified technology company 3M is a disposable depth filtration system for cell culture clarification or downstream impurity removal.
The Zeta Plus Encapsulated Filter System from diversified technology company 3M is a disposable depth filtration system for cell culture clarification or downstream impurity removal. It consists of a small system suited to lab or pilot scale production and a large system for production scale biomanufacturing. Both comprise a filter holder, disposable manifolds, and a flexible number of capsule filters. The ergonomically designed large filter holder can be pivoted between the horizontal and vertical position to allow convenient loading and unloading at waist height, as well as minimal footprint during filtration and reduced fluid spills. Two capsule configurations are available for use with the system: the 0.23 m2 capsule is designed for use with the small holder and the 1.6 m2 capsule is designed for use with both holders, offering a high degree of process flexibility. The latter has a CAM locking mechanism for a fast, easy, robust capsule-to-capsule connection.
A Novel, Enhanced, and Sustainable Approach to Audit Trail Review
July 4th 2025Eli Lilly and Company developed an innovative and sustainable approach to audit trail review (ATR) aimed at reducing the ATR burden while adhering to regulatory expectations and data integrity (DI) principles. The process has transformed employees' understanding of ATR and complemented the DI by design approach, leading to better system designs that meet expected controls and reduce non-value-added data reviews.
Drug Solutions Podcast: Novel Drug Delivery Approaches: Refining AAV Vector Deliveries
May 30th 2025In this podcast episode, we discuss novel approaches to drug delivery, specifically regarding adeno-associated virus (AAV) vectors, as viewed by two industry experts who recently exhibited at the annual ASGCT meeting.
Transformations in Drug Development for Cell and Gene Therapies
March 28th 2025As a recognized leader in immunophenotyping for clinical trials, Kevin Lang from PPD discusses how spectral flow cytometry is transforming drug development, particularly in cell and gene therapies like CAR-T. He also dives into his award-winning research, including his 2024 WRIB Poster Award-winning work, and his insights from presenting at AAPS PharmSci360.