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Gastroesophageal reflux disease (GERD) is a digestive disorder that develops from continuous exposure of the esophagus to acidic reflux from the stomach. Raft-forming anti-reflux preparation is one line of treatment wherein a viscous gel forms a physical barrier above the stomach contents and prevents it from refluxing back into the esophagus. Sodium alginate is one of the key ingredients in such formulations.

The aim of this presentation is to highlight the effect of various formulation components on the raft properties. Additionally, a novel method for raft testing will be introduced, which will help to provide a deeper understanding about the resistance of the gels against applied forces under 

 conditions. We will then correlate this raft strength data and the testing to understand the behavior in 

Comparison of different alginate sources according to raft performance

Characterization of the rheo-mechanical properties of the sodium alginate raft for overall strength and recoverability of raft under applied shear forces

Introduction of a novel method to characterize raft resistance against applied shear force

 Rathnakar Palarapu, Analytical Team Leader, Pharma Solutions, DuPont Nutrition & Biosciences

Dr. Matthias Knarr, Research Scientist, Pharma Solutions, DuPont Nutrition & Biosciences

Webcasts

*** Available On Demand *** The aim of this presentation is to highlight the effect of various formulation components on the raft properties. ***On demand available after final airing until Dec. 21, 2021***



Advanced characterization of sodium alginate raft strength for the treatment of gastroesophageal reflux disease 

https://www.pharmtech.com/pt_w/optimized_performance

What if one excipient family could deliver consistency and performance across a range of drug formulation applications—from traditional methods like direct compression to novel and unique applications? What if digital tools could predict the probability of the success or failure of a pharmaceutical formulation?

Cellulosics are one of the most versatile excipients, but given the natural variability inherent in the ingredient, they need to be applied with precision—and help from digital tools—to deliver the needed result. In this webinar, we’ll cover:

How the critical material attributes and mechanism of action of cellulosic polymers correlates to formulation performance, enabling predictable results from these excipients

How data analytics and digital tools can ensure quality, batch-to-batch consistency and help formulate more robust formulations

How customized grades of cellulosics can be used to solve common problems related to immediate- and modified-release formulations—and improve performance

Explore the different types of cellulosics, their critical material attributes and their ability to deliver performance across applications.

Learn how data analytics can solve the toughest challenges in consistency and quality

Understand the top formulation challenges cellulosics can solve

True Rogers, R.Ph., Ph.D., Senior Research Scientist, Pharma Solutions, DuPont Nutrition & Bioscience

Yeli Zhang, Ph.D., Technical Service Manager, Pharma Solutions, DuPont Nutrition and Biosciences

: Thursday, November 19, 2020 at 11am EST| 8am PST| 4pm GMT| 5pm CET

On demand available after final airing until Nov. 19, 2021

***Live: Thursday Nov 19, 2020 at 11am EST| 8am PST| 4pm GMT| 5pm CET*** Managing polymer variability is critical in developing robust formulations and processes. Cellulose is not only one of the most abundant compounds on Earth, but also one of the most versatile ingredients in the pharmaceutical industry. Learn how its critical material attributes can be customized—from manipulating physical properties like particle size for improved processibility   to modifying chemical properties such as substitution and molecular weight, which impacts drug release. 

This webinar will demonstrate how cellulosic structural property performance fundamentals can help a formulator design the highest quality and most robust drug product formulation.

Further, the addition of digital tools can ensure better batch-to-batch consistency and predict other quality parameters, further optimizing a formulation to your needs. 
 *** On demand available after final airing until Nov. 19, 2021.***


How Polymer Expertise and Data Analytics Can Deliver Optimized Performance and Processes for Your Formulations

http://www.pharmtech.com/pt_w/pharma_facilities


	Contamination control has always been a leading concern for bio/pharmaceutical facilities and operations. Facility and HVAC design, process workflows, and standard operating procedures for personnel and equipment are all designed to protect the product and people.

	The COVID-19 pandemic requires bio/pharma companies to look beyond good manufacturing practices to assess the how the potential spread of the virus may impact different areas of development and manufacturing facilities, employees, visitors, and product.

	In this webcast, experts will review strategies for evaluating practices at existing facilities and will discuss options for designing new facilities that can accommodate future needs, including flexibility requirements and any emerging threats. 

		Moving beyond basic maintenance procedures

		Using airflow modeling and simulation to optimize manufacturing, personnel, and material flow 

		Strategies for rapid process scale up, changeovers, and return to full capacity

		Implementing science-based design principles for innovative, affordable facility designs

	This Editors’ Series webcast is presented by 

 magazine, in conjunction with INTERPHEX.

Jason S. Collins, AIA, Director, Process Architecture, IPS

	Curt Firestine, Mechanical Engineer, CRB

Tuesday, May 26, 2020 at 2 pm EDT| 1pm CDT| 11am PDT

	On demand available after airing until May 26, 2021

The COVID-19 pandemic should prompt bio/pharma facilities to assess how the potential spread of the virus may impact different areas of development and manufacturing facilities, employees, visitors, and product. Learn about strategies for evaluating practices at existing facilities and options for designing new facilities that can accommodate future needs, including flexibility requirements and any emerging threats. 

Live: Tuesday, May 26, 2020 at 2 pm EDT| 1pm CDT| 11am PDT

On demand available after airing until May 26, 2021

Register free



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