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Michalakis Savva

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Error Assessment of Drug Concentration in Multicomponent Pharmaceutical Mixtures

Error Assessment of Drug Concentration in Multicomponent Pharmaceutical Mixtures

Michalakis Savva
February 1st 2016

A novel method, based on differential calculus, was used to calculate the maximum potential error associated with the drug concentration in pharmaceutical mixtures composed of an infinite number of ingredients measured on an infinite number of balances with different sensitivities. The method was further applied to calculate the ingredients’ least allowable quantities. This approach ensures that the pharmaceutical formulation is prepared within a given maximum permissible error in drug dose.

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