Suggy S. Chrai

Liposomal formulations are increasingly being used in biopharmaceutical development projects. Good manufacturing processes must reproducibly fabricate lipid vesicles that are as uniform in size as possible, carry the drug in sufficient concentrations and remain stable for an acceptable shelf-life at varying temperatures. This article highlights some relevant production issues, such as drug incorporation, characterization and stability.

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Non-toxic and biodegradeable, biologically active liposomes encapsulate therapeutics to provide an attractive drug delivery system for the future.

Liposomes, Part II: Drug delivery systems

In Part I of this two-part series, the authors discuss the need to follow GMPs for lipid-vesicle fabrication that result in size uniformity, delivery of sufficient drug concentration, and stability.