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Lubrication in Continuous Tubular Powder BlendersShear-sensitive ingredients in a tableting formulation experience different conditions in a batch tumble blender than they would in a continuous paddle blender.
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Optimizing Loss-in-Weight Feeding of Poorly Flowing MaterialsPrior to use in a continuous manufacturing system for oral solid dosage forms, loss-in-weight feeders need to be tested and validated to understand the performance capabilities of a given material–feeder combination. In this article, the proper strategy for set-up and optimization of a loss-in-weight feeder is demonstrated for a range of materials. The optimized set-up of the feeders was demonstrated to provide suitable performance for even the most challenging, poorly flowing materials.
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Sandoz Recalls Cefazolin Due to Mispackaging, Opens Biosimilar Facility in SloveniaThe company is voluntarily recalling one lot of cefazolin for injection, USP, 1 gram per vial due to customer complaints of the wrong product being included in a carton.
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Pharmapack Europe 2025: Packaging TrendsPharmaceutical Technology® sat down with Stefan Verheyden, Global Vice President Sales Pharma & Biopharma Solutions Injectables at Gerresheimer, to talk about the primary and secondary packaging solutions Gerresheimer and Bormioli Pharma will be showcasing at Pharmapack Europe 2025 in Paris, France from January 22–23.
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The Necessity of Prioritizing Cleaning ValidationWith COVID-19 vaccine facilities receiving recent citations, it is evident that failure to meet cleaning and sanitization requirements puts patients, facilities, and operators at risk.
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Necessity Drives Just-in-Time Approaches to Clinical Trials SupplyThe COVID-19 pandemic is pushing more companies to adopt just-in-time practices, but success demands careful upfront risk assessment and planning.
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Tableting—a Focus for Continuous ImprovementEfforts to tackle challenges in tablet manufacture are shaped by quality by design (QbD) and continuous manufacturing.
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Assessing the E&L Risk in Biologic DrugsTo ensure the safety and efficacy of biologic drug products, the materials that come in contact with the drug must be fully characterized to determine their impact.
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Developing Lipid-Based FormulationsLipid-based formulations offer a means of addressing the physicochemical and biological challenges of poorly soluble APIs.
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Prefilled Syringes Meet Growing DemandInnovations in glass and plastic syringes reduce waste and increase safety.
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Innovations in Prefilled BiologicsPackaging and packaging line innovations are addressing the industry’s growing use of biologics.
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Advancing Robotic AutomationNew technologies improve efficiency and remove operator intervention.
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Exploring 3D Printing for Solid Dosage DrugsAs a GMP manufacturing method, 3D printing offers benefits for modified release and personalized dosages.
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Predicting Moisture Uptake in Solid Dosage PackagingMoisture uptake during the end-to-end manufacturing process and supply chain can affect product quality. Simulation tools based on mechanistic models help define storage and handling requirements for oral solid-dosage drugs.
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Best Practices: How to Avoid the Five Common Pharma Packaging and Labelling Artwork HurdlesThis article looks at five of the most common hurdles in packaging and labelling artwork and how to avoid them.
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Evaluating Mixing in a Single-Use Bioprocessing SystemQuantitative and qualitative tools allow better understanding of mixing in a single-use bioprocessing system.
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From Bitter to Sweet: Developing a User-Friendly PainkillerHot-melt coating was used to develop taste-masked orally disintegrating granules of acetaminophen and caffeine.
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From Bitter to Sweet: Developing a User-Friendly PainkillerHot-melt coating was used to develop taste-masked orally disintegrating granules of acetaminophen and caffeine.
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Overcoming Low Endotoxin RecoveryUnderstanding of endotoxin assays and a range of detection technologies are essential for effective testing.
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Enhancing API Solubility During API Processing and Formulation Development MerckUnderstanding the impact of API solubility on the performance of a given drug product and determining ways to enhance dissolution rates is critical to ensuring your product makes it to market, into the hands of patients and clinicians, is well absorbed and provides its intended therapeutic effect. Selecting the best formulation strategy to address challenges for each API, however, can be time-consuming, costly and complex.
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GE Healthcare: The Next Cell and Gene Therapy Manufacturing Giant?GE Healthcare continues to ramp up its offerings in the bioprocessing space with the purchase of Asymptote and a continued partnership with Zenith Technologies.
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Boosting Bioproduction Workflows with Automation TechnologiesAs cost pressures mount as a result of multiple biologics being developed for the same indication, manufacturers can harness process efficiencies to maintain the value of legacy products.
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What Ifs in the Five-Year PlanHeightened uncertainty means CDMO executives need to play out planning scenarios.
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Adapting Regulations Post-BrexitThe UK government is taking advantage of the new regulatory flexibility, afforded by Brexit, to boost the country’s competitiveness in pharma.
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Business on Hold? EMA’s Full Recovery in QuestionEMA is facing a dilemma in trying to restore activities back to normal after relocating and the COVID-19 pandemic.
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Signing Off from WashingtonFDA and industry face unprecedented political and policy challenges.
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FDA Highlights Value and Challenges of Advanced Drug ManufacturingFDA is expanding its Emerging Technology Program and providing more support for new drug applications that present advanced manufacturing technologies.
