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Saranjit Singh is a professor and head of the department of pharmaceutical analysis at the National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160062, India, tel. 91 172 214682, fax 91 172 214692.
K. Venugopal is a postgraduate student from the National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S. Nagar 160 062, India, presently working at Ranbaxy Research Laboratories (Gurgaon, India).
Eventual change in the dissolution characteristics of some dosage forms, which is ascribed to cross-linking of gelatin, continues to present challenges to drug manufacturers. The authors discuss the causes, mechanisms, and solutions to the problem.