Benchtop Crossflow Filtration System for Downstream Biopharm

Sartoflow Smart from Sartorius Stedim Biotech (SSB) is a benchtop crossflow system for low-volume ultra- and diafiltration applications. It can be used in downstream processes, such as purification of vaccines, monoclonal antibodies, and recombinant proteins.

The flexible system can be used in laboratory environments for process development and clinical trials as well as in cGMP environments. A low-shear, four-piston membrane pump enables high product yields and provides a wide range of flow rates. Membrane surface areas range from 50 cm² to 0.14 m².

The crossflow system is supplied with SSB’s intuitive DCU-4 control unit, which, when combined with the company’s BioPAT SCADA, MFCS-4 software, provides data logging and export. Its touchscreen offers instant access to all critical process parameters and displays control and alarm functions. A logbook function stores alarms, set points, and user logs. A touchscreen supports the operator with interactive prompts for guidance through process sequences. Users can select predefined parameters to automatically run sequences for concentration, diafiltration, rinsing, filling, draining, flushing steps, and tare functions.

An optional peristaltic diafiltration pump is available to load product or buffer as a discrete process step. The system can be customized by installing a conductivity, pH, or temperature probe in the recirculation vessel. The system can also be upgraded in the case of changing process requirements.

Source: Sartorius Stedim Biotech