Controlled Crystallization During Freeze-Drying

Article

Pharmaceutical Technology Europe

Pharmaceutical Technology EuropePharmaceutical Technology Europe-08-01-2011
Volume 23
Issue 8

The authors discuss the preparation of lipophilic drug nanocrystals by controlled crystallization during freeze-drying.

By Hans de Waard, Niels Grasmeijer, Wouter L.J. Hinrichs, Thomas De Beer and Henderik W. Frijlink

The authors discuss the preparation of lipophilic drug nanocrystals by controlled crystallisation during freeze-drying (CCDF). In-line Raman spectroscopy was used to monitor the crystallisation of the drug during freeze-drying to elucidate how the size of the drug crystals could be controlled. A three-way nozzle was used to create a spray freeze-drying process suitable for large-scale production.

This article was also published in our US sister publication Pharmaceutical Technology and can be read here.

Articles in this issue
Improving API Synthesis
Understanding Fluidized-Bed Granulation
Controlled Release from Porous Platforms
Controlled Crystallization During Freeze-Drying
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The Importance Of Filter Testing
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Croatia, Pharma and Corruption
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