Understanding Fluidized-Bed Granulation

By A. Burggraeve, T. Van Den Kerkhof, M. Hellings, J.P. Remon, C. Vervaet and T. De Beer

The authors incorporated a particle-size analyser into a laboratory-scale top-spray fluid-bed granulator to monitor granule size distribution (GSD) continuously during granulation. A two-level full-factorial design was used to study the influence of several process and formulation variables on the end-product GSD, measured in-line with spatial-filter velocimetry (SFV).