Article

Pharmaceutical Technology Europe

Pharmaceutical Technology Europe

Pharmaceutical Technology Europe-08-01-2011
Volume23
Issue 8

Understanding Fluidized-Bed Granulation

Author(s):

This study demonstrates the beneficial use of a spatial-filter velocimetry particle-size analyzer during granulation.

By A. Burggraeve, T. Van Den Kerkhof, M. Hellings, J.P. Remon, C. Vervaet and T. De Beer

The authors incorporated a particle-size analyser into a laboratory-scale top-spray fluid-bed granulator to monitor granule size distribution (GSD) continuously during granulation. A two-level full-factorial design was used to study the influence of several process and formulation variables on the end-product GSD, measured in-line with spatial-filter velocimetry (SFV).

This article was also published in our US sister publication Pharmaceutical Technology and can be read here.

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Related Videos
 Benjamin McLeod and Sebastian Lykke Skafte Andersen go behind the headlines to examine the motivations behind recent M&A activity, tariff responses, and more.