Article
Pharmaceutical Technology Europe
Pharmaceutical Technology Europe
Author(s):
This study demonstrates the beneficial use of a spatial-filter velocimetry particle-size analyzer during granulation.
By A. Burggraeve, T. Van Den Kerkhof, M. Hellings, J.P. Remon, C. Vervaet and T. De Beer
The authors incorporated a particle-size analyser into a laboratory-scale top-spray fluid-bed granulator to monitor granule size distribution (GSD) continuously during granulation. A two-level full-factorial design was used to study the influence of several process and formulation variables on the end-product GSD, measured in-line with spatial-filter velocimetry (SFV).
This article was also published in our US sister publication Pharmaceutical Technology and can be read here.
Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.