Understanding Fluidized-Bed Granulation

J.P,Remon;A,Burggraeve;C,Vervaet;T. De,Beer;Van Den,Kerkhof;M,Hellings;

Understanding Fluidized-Bed Granulation

Published on: August 1, 2011

J.P. Remon, A. Burggraeve, C. Vervaet, T. De Beer, T. Van Den Kerkhof, M. Hellings

Pharmaceutical Technology Europe

Pharmaceutical Technology Europe, Pharmaceutical Technology Europe-08-01-2011, Volume 23, Issue 8

This study demonstrates the beneficial use of a spatial-filter velocimetry particle-size analyzer during granulation.

By A. Burggraeve, T. Van Den Kerkhof, M. Hellings, J.P. Remon, C. Vervaet and T. De Beer

The authors incorporated a particle-size analyser into a laboratory-scale top-spray fluid-bed granulator to monitor granule size distribution (GSD) continuously during granulation. A two-level full-factorial design was used to study the influence of several process and formulation variables on the end-product GSD, measured in-line with spatial-filter velocimetry (SFV).

This article was also published in our US sister publication Pharmaceutical Technology and can be read here.