Spectrophotometer System Automatically Handles Samples for Dissolution Testing

An ultraviolet light (UV) spectrophotometer system from Hanson Research automatically handles samples for pharmaceutical dissolution and diffusion testing.

An ultraviolet light (UV) spectrophotometer system from Hanson Research automatically handles samples for pharmaceutical dissolution and diffusion testing. Previous versions of the company’s modular dissolution testers and autosamplers offer a flexible, semi-automated approach for both immediate-release and extended-release dosage forms. These systems are semi-automated because the dissolution samples are collected into capped vials or test tubes but then are processed off-line by UV or high-performance liquid chromatography (HPLC) by the user. With Hanson’s new system, the samples are automatically pushed into flow cells where UV absorbance readings will take place before the samples are then collected into capped test tubes or returned back to the vessels.

The system uses Shimadzu’s UV-1800 spectrophotometer and Solvias’ ARGUS/Dissolution software. The systems are scalable and configurable starting with one dissolution tester and a peri-pump up to three-bath systems using precision autosampling. This modularity can accommodate simpler dissolution runs or complex methods and high throughput.

Source: Hanson Research