Whitepapers

Lipid formulation and spray-dried dispersions are widely used, and proven technologies to overcome bioavailability challenges for poorly soluble molecules. For selecting the most suitable formulation technologies in early-phase development, formulation scientists regard efficacy, safety, bioavailability and stability as their top priorities. However, an early-phase formulation strategy should also consider scale-up and manufacturing challenges that may arise later in development. If bioavailability and manufacturing challenges are not addressed in early development, the cost and overall timeline of the project may be negatively impacted. Therefore, developing a bioavailable formulation that is easy to scale-up with superior dose uniformity is imperative for a product’s success.

Critical considerations for deploying smart, fast, and flexible Life Sciences facilities

Tailored manufacturing capabilities are critical in a CDMO. But, when you’re sprinting to market with a niche product, a partner who can also source your raw materials and de-risk your regulatory pathway is everything. With the right partner, every point along the development and manufacturing value chain journey becomes accelerated.

Through advanced technology, deep industry knowledge and an unwaveringly collaborative approach, our proven capabilities help life sciences companies succeed in a highly competitive and complex marketplace from targeted biologics to cybersecurity.

Partner Smart with End-to-End CDMO. What if you could rely on one partner to source APIs, formulate and develop drug products, and manufacture at clinical and commercial scale? Rather than too many links in your supply chain, an end-to-end CDMO reduces layers of administration, gaps in knowledge, time, cost, and risk.

Cybersecurity with Clarity and Rockwell Automation

Get ahead of cyber-attacks by keeping pace with the speed of IIoT innovation

Optimizing API Procurement. Supply chain woes existed long before the pandemic, and not many scientists want to spend time sourcing ingredients. There is a way to ensure you get the right active pharmaceutical ingredients, at the right cost, with the right plan to scale: partnering with an API procurement and supply chain specialist.

Review testing requirements for lab balances in the pharmaceutical industry described in the relevant pharmacopoeias and the associated certificates offered by Sartorius.

This technical brief will start by outlining the importance of cross-coupling catalysts in the industry. It will then weigh up the benefits of existing in situ and pre-formed catalysts. The remainder of the technical brief introduces Johnson Matthey’s DyadPalladateTM pre-catalysts as a cost-effective and greener alternative to traditional in situ systems.

Peptide modification via salts is a way to change properties of the API to make it more advantageous to the desired release profile.

A long-acting injectable improves the patient’s experience by only requiring a once weekly, or monthly injection as opposed to a daily dosing regimen. The gel depot formulation is simple to manufacture, and easy to tune to the desired release duration and dose.

The recently introduced NanoFlowSizer instrument employing novel ‘Spatially Resolved Dynamic Light Scattering’ (SR-DLS) provides a breakthrough in inline nanoparticle sizing

We demonstrate the wide range of customized products and services that Actylis offers its biopharma customers.

We showcase Actylis, what the company stands for and how we serve our broad-ranging customer base globally.

We look at the importance of finding suppliers able to develop and customise Process Intermediates to meet the rapidly-changing expectations of modern finished drug manufacturers, and the economic & logistic benefits of outsourcing Buffer manufacturing, especially with the rise of cell & gene therapy products.

In this whitepaper we explore the role of GMP-grade Phenylmethylsulfonyl fluoride and other protease inhibitors in biopharmaceutical manufacturing, and we outline how Actylis’ high-purity and refined PMSF helps finished drug manufacturers to meet increasingly rigorous regulatory requirements.

We provide a list of readily available high-quality biopharma ingredients used for in vitro diagnostics, vaccines, cell cultures and preservatives that we keep on hand to service our biopharma customers. All these raw materials have a very short lead time to suit your rapidly-changing manufacturing needs.

Our in-house experts, along with Cecile Bellamy from Pfizer, deep dive into the factors that are influencing our industry today and look at what trends are likely to impact us in the future. We cover topics including regulatory compliance, manufacturer flexibility & supply chain risk and debate the supplier vs partner relationship and the importance of collaboration as we face a challenging future.

Read a compelling, detailed Case Study about how an innovation partnership with Waters Corporation enhanced Alcami’s capacity, efficiency, and compliance-readiness for their pharmaceutical manufacturing and analytical services to differentiate their offerings and drive business growth.

Biologics manufacturers have been successful boosting yields and increasing throughput in upstream mAbs production. Those increased volumes create a new challenge: scaling downstream process chromatography to be as productive. This Avantor white paper details how technologies such as a novel protein A chromatography resin and the use of additives can improve efficiencies in this complex process step. The white paper also explores the benefits of expanding single-use and continuous processing systems to further streamline downstream production and improve cost profiles.

A present investigation aimed to evaluate the impact of commonly used different binder-diluent ratios on the tablet's mechanical strength to propose a binder-diluent scale.

Pediatric formulations have become increasingly important as the healthcare field recognizes the huge impact that strict patient adherence can have on a treatment’s efficacy. But to overcome the challenges of adherence in children, drug developers need to consider innovative new dosage forms that can deliver flexible and convenient medications for young patients.